T S of Animal Cells by Carol
نویسنده
چکیده
Many purified plant lectins specifically interact with the carbohydrate moieties of glycoproteins and glycolipids at the cell surface and are cytotoxic (1, 2). Lectinresistant mutants o f animal cells have been isolated which have alterations in cell membrane molecules (3-6). It was found that a series of iectin-resistant mutants we isolated were much more sensitive to the cytotoxic activity o f normal rabbit serum than was the parental Chinese hamster ovary (CHO) cell line. T h e hypothesis that naturally occurr ing antibodies in rabbit serum are reacting with incomplete carbohydra te chains on the lectin-resistant mutants to cause this increased sensitivity is explored.
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